Publications by authors named "A Bienvenu"
Antifungal resistance in humans is a clinical reality of increasing incidence that raises problems for patient care. In this current event, we discuss the link that can be made between the presence of antifungals in the environment and the development of resistance in humans, as well as the ecotoxicology of antifungals. The presence of antifungals in the environment has a health, but also an ecological impact.
View Article and Find Full Text PDFGiven its good tolerance and broad-spectrum, isavuconazole is increasingly used off-label as an empirical therapy of invasive fungal infections. We retrospectively reviewed isavuconazole empirical treatment during a 12-month period in four hospitals. During isavuconazole treatment (n=27), none of the patients had a mycological evidence for fungal infection, but 19% (5/27) developed liver test abnormalities without leading to isavuconazole discontinuation.
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- The study investigates the pharmacokinetics (PK) of fluconazole in critically ill patients to identify optimal dosing regimens due to reported variability in drug response.
- A retrospective analysis included 36 critically ill and 16 non-critically ill patients, revealing that standard dosing often results in inadequate drug levels, particularly against certain pathogens.
- Findings suggest that higher loading doses are essential for meeting pharmacodynamic (PD) targets, particularly against stronger fungal infections, indicating a need for reconsideration of fluconazole use in severe cases.*
Through their footprint throughout their life cycle, from production to use, medicines have a significant impact on the environment. Reducing this impact is rarely considered from the perspective of the choices that healthcare professionals might have to make when prescribing or dispensing medicines. Should we consider environmental impact, alongside effectiveness and tolerance, one of the dimensions of the proper use of medicines? To address this question, the 5th Forum of the Association for the Proper Use of Medicines highlighted the main sources of pharmaceutical pollution: the carbon footprint linked to production, greenhouse gas emissions, the impact of residues on water and waste from packaging.
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- Intracellular bacterial pathogens manipulate host cell processes to create a suitable environment for their survival, with the Q fever bacterium using its Type 4 secretion system to form a specialized vacuole known as a CCV.
- The study identifies that the bacterial effector protein Vice interacts with specific lipids (like phosphatidylserine) and triggers the formation of compartments similar to CCVs in host cells, demonstrating its role in both vacuole formation and stabilization.
- Vice performs dual functions: first aiding in the internalization of vacuoles through macropinocytosis, and then disrupting the ESCRT machinery to maintain these compartments, highlighting its key role in bacterial replication and survival.