Publications by authors named "A Bieger"
Article Synopsis
- The study examines how recent updates in Alzheimer's disease diagnostic guidelines from NIA-AA and IWG impact clinical diagnoses among cognitively unimpaired and impaired individuals.
- It analyzed clinical and biomarker data from 1,195 participants, noting differences in diagnostic labels assigned under various guidelines and the frequency of discordant diagnoses among them.
- The findings revealed significant variance in predictive value for cognitive impairment across different diagnostic frameworks, with older guidelines showing a clearer correlation than some of the more recent ones.
Clinical Correlates of the PET-based Braak Staging Framework in Alzheimer's Disease.
J Prev Alzheimers Dis
February 2024
In vivo Alzheimer's disease diagnosis and staging is traditionally based on clinical features. However, the agreement between clinical and pathological Alzheimer's disease diagnosis, whose diagnosis assessment includes amyloid and Braak histopathological tau staging, is not completely convergent. The development of positron emission tomography (PET) tracers targeting neurofibrillary tangles offers prospects for advancing the staging of Alzheimer's disease from both biological and clinical perspectives.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers found that a higher VRF burden is linked to increased neurodegeneration and cognitive decline over time, indicating these factors work together to worsen AD.
- * Despite VRFs and AD pathophysiology operating independently, combining treatments aimed at both could improve outcomes for individuals at risk for AD, especially in its early stages.
Neuroinflammation Biomarkers in the AT(N) Framework Across the Alzheimer's Disease Continuum.
J Prev Alzheimers Dis
June 2023
In the past years, neuroinflammation has been widely investigated in Alzheimer's disease (AD). Evidence from animal, in vivo and post-mortem studies has shown that inflammatory changes are a common feature of the disease, apparently happening in response to amyloid-beta and tau accumulation. Progress in imaging and fluid biomarkers now allows for identifying surrogate markers of neuroinflammation in living individuals, which may offer unprecedented opportunities to better understand AD pathogenesis and progression.
View Article and Find Full Text PDF