Publications by authors named "A Bertoldi"
Hitting the target: cell signaling pathways modulation by extracellular vesicles.
Extracell Vesicles Circ Nucl Acids
September 2024
Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released outside the cell. EVs have drawn attention not only for their role in cell waste disposal, but also as additional tools for cell-to-cell communication. Their complex contents include not only lipids, but also proteins, nucleic acids (RNA, DNA), and metabolites.
View Article and Find Full Text PDFThe growing interest in plant-origin active molecules with medicinal properties has led to a revaluation of plants in the pharmaceutical field. Plant-derived extracellular vesicles (PDEVs) have emerged as promising candidates for next-generation drug delivery systems due to their ability to concentrate and deliver a plethora of bioactive molecules. These bilayer membranous vesicles, whose diameter ranges from 30 to 1000 nm, are released by different cell types and play a crucial role in cross-kingdom communication between plants and humans.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines the rise of chronic conditions among older adults in Southern Brazil over six years, focusing on how demographic, socioeconomic, and behavioral health factors impact this trend.
- - Researchers analyzed data from 1,098 participants aged 60 and older, finding that 30.9% had a low burden of conditions, 52.0% a moderate burden, and 17.1% a high burden, with various factors influencing risk levels.
- - The findings suggest that a majority of older adults experience a moderate number of chronic conditions, and specific characteristics such as being male, older age, lack of education, and being a former smoker are linked to a higher burden of these conditions.
Brazil is characterized by an unfinished agenda of health inequalities, which impact health problems in the childhood. This study aimed to evaluate the socioeconomic inequalities of health problems in the early childhood. This is a prospective study, using data from the birth cohort carried out in the city of Pelotas (Rio Grande do Sul State, Brazil) in 2015.
View Article and Find Full Text PDFParvovirus B19 remains an underestimated pathogen among infections during gestation in Argentina: Insights through the study of symptomatic and asymptomatic pregnant patients and newborns from Córdoba.
J Clin Virol
December 2024
Article Synopsis
- Parvovirus B19 infection during pregnancy can lead to serious issues for the fetus; this study aimed to examine both symptomatic and asymptomatic cases, focusing on virological markers and the virus's genetic sequencing in Argentina.
- The research involved analyzing 328 symptomatic patients, including 185 pregnant women and their newborns, leading to a total of 27 positive B19 V cases, with some instances of vertical transmission from mother to baby.
- The study's results emphasize the importance of improving awareness and diagnostic strategies in Argentina to better detect and manage B19 V infections during pregnancy.