Unveiling underutilized public data on Canadian industrial pollutant transfers and disposals.

Over 50 nations worldwide have Pollutant Release and Transfer Registers (PRTRs), including Canada's National Pollutant Release Inventory (NPRI), which comprise large public datasets of chemical releases to air, water, and land and also transfers to various on and off-site waste management practices. These inventories aim to support a myriad of audiences in pollution-related decision-making. While the Organisation for Economic Cooperation and Development (OECD) framed a role for PRTRs as indicators for Sustainable Development Goal (SDG) 12 - the sound management of chemicals and wastes, research to date has focused only on air and water releases, omitting vast PRTR data on pollutant transfers to waste management.

Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease.

Positive modulation of hepatocyte growth factor (HGF) signaling may represent a promising therapeutic strategy for Alzheimer's disease (AD) based on its multimodal neurotrophic, neuroprotective, and anti-inflammatory effects addressing the complex pathophysiology of neurodegeneration. Fosgonimeton is a small-molecule positive modulator of the HGF system that has demonstrated neurotrophic and pro-cognitive effects in preclinical models of dementia. Herein, we evaluate the neuroprotective potential of fosgonimeton, or its active metabolite, fosgo-AM, in amyloid-beta (Aβ)-driven preclinical models of AD, providing mechanistic insight into its mode of action.

ATH-1105, a small-molecule positive modulator of the neurotrophic HGF system, is neuroprotective, preserves neuromotor function, and extends survival in preclinical models of ALS.

Introduction: Amyotrophic lateral sclerosis (ALS), a progressive and fatal neurodegenerative disorder, primarily affects the motor neurons of the brain and spinal cord. Like other neurodegenerative conditions, ongoing pathological processes such as increased inflammation, excitotoxicity, and protein accumulation contribute to neuronal death. Hepatocyte growth factor (HGF) signaling through the MET receptor promotes pro-survival, anti-apoptotic, and anti-inflammatory effects in multiple cell types, including the neurons and support cells of the nervous system.

New Sustainability Perspectives on Pollutant Releases from Canada's Nuclear Sector.

This novel characterization of new Canadian radionuclide release data aims to both deepen the understanding of the nature and magnitude of present-day emissions from nuclear facilities and accelerate the tracking of this sector's progress toward United Nations Sustainable Development Goal (SDG) 12 (responsible consumption and use patterns) and target 12.4 (environmentally sound chemicals management). Further novel perspectives on the role of this data as an indicator of sustainability are discussed by merging it with other pollutant releases from this sector, as reported to the National Pollutant Release Inventory (NPRI), to fill gaps in the latter's substance coverage.

Radionuclide contamination in Canada: A scoping review.

Radionuclides were first discovered in the late 1800s, and artificial (anthropogenic) radionuclides in the 1930s. Since then, this group of substances has been increasingly incorporated into various peaceful and non-peaceful applications across Canada and the world, bringing with it both advanced technological and medical benefits, and public concern about the dangers from radiation exposure. As such, a breadth of research on, and monitoring of, radionuclides in the Canadian environment has been generated, the results of which span decades.