Publications by authors named "A Berthet"
Introduction: Many tobacco smokers try to quit with electronic nicotine delivery systems (ENDS or e-cigarettes). We aimed to describe e-liquid flavors and nicotine concentration use over 6 months in a prospective cohort of smokers willing to quit with ENDS.
Methods: We included 622 participants from the intervention group of the Efficacy, Safety and Toxicology of ENDS randomized controlled trial.
Article Synopsis
- Alternative plasticizers like DINCH, DEHTP, and DEHA are being used to replace phthalates in products due to reproductive concerns associated with phthalates.
- A study aimed to assess how well these substitutes are absorbed through human skin and confirmed the findings with human volunteer tests, measuring metabolite levels in urine.
- Results indicated that DEHTP and DINCH did not significantly penetrate the skin, while DEHA had minimal absorption; consequently, participants showed low levels of urinary metabolites after exposure.
Polychlorinated dibenzo--dioxin and dibenzofuran contamination of free-range eggs: estimation of the laying hen's soil ingestion based on a toxicokinetic model, and human consumption recommendations.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
October 2024
Polychlorinated dibenzo--dioxins and dibenzofurans (PCDD/Fs) are ubiquitous in the environment. The main route of human exposure is through food consumption. Soil contamination can be problematic for sanitary safety depending on the usage of the soil, such as farming.
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- Population studies indicate that many people are exposed to phthalates, chemicals linked to various health concerns, making it crucial to understand how they are absorbed through the skin and eliminated from the body.
- This study specifically examines the skin permeation of three phthalates (d4-DEHP, d4-DBP, and d4-DEP) and found that they can cross the skin barrier and are metabolized into smaller forms called monoesters before being excreted in urine.
- Results revealed that phthalates in an emulsion (a mixture with PEG) were absorbed more effectively through the skin compared to their neat forms, with different absorption rates and urinary excretion patterns observed
Background: Electronic nicotine-delivery systems - also called e-cigarettes - are used by some tobacco smokers to assist with quitting. Evidence regarding the efficacy and safety of these systems is needed.
Methods: In this open-label, controlled trial, we randomly assigned adults who were smoking at least five tobacco cigarettes per day and who wanted to set a quit date to an intervention group, which received free e-cigarettes and e-liquids, standard-of-care smoking-cessation counseling, and optional (not free) nicotine-replacement therapy, or to a control group, which received standard counseling and a voucher, which they could use for any purpose, including nicotine-replacement therapy.