Publications by authors named "A Bert Chabot"
Hematopoietic stem cells (HSCs) sustain life-long hematopoiesis and emerge during mid-gestation from hemogenic endothelial progenitors via an endothelial-to-hematopoietic transition (EHT). The full scope of molecular mechanisms governing this process remains unclear. The NR4A subfamily of orphan nuclear receptors act as tumor suppressors in myeloid leukemogenesis and have never been implicated in HSC specification.
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- The text discusses the importance of certain proteins in regulating CXCR4, which is crucial for B-cell movement and function in the germinal center.
- It highlights that the absence of specific genes can lead to abnormal B-cell development, increased mutation rates, and a high risk of developing aggressive B-cell cancers in mice.
- Additionally, the study suggests that these gene deficiencies create a model that mimics human aggressive B-cell lymphomas, offering insights into the mechanisms behind these blood cancers.
Purpose: Clinical efficacy of chimeric antigen receptor (CAR) T cells against pediatric osteosarcoma (OS) has been limited. One strategy to improve efficacy may be to drive chemokine-mediated homing of CAR T cells to tumors. We sought to determine the primary chemokines secreted by OS and evaluate the efficacy of B7-H3.
View Article and Find Full Text PDFHematopoietic stem cells (HSCs) can generate all blood cells. This ability is exploited in HSC transplantation (HSCT) to treat hematologic disease. A clear understanding of the molecular mechanisms that regulate HSCT is necessary to continue improving transplant protocols.
View Article and Find Full Text PDFThe use of biological inputs is an interesting approach to optimize crop production and reduce the use of chemical inputs. Understanding the chemical communication between bacteria and plants is critical to optimizing this approach. Recently, we have shown that (.
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