Publications by authors named "A Bernini"
Living systems cannot rely on random intermolecular approaches toward cell crowding, and hidden mechanisms must be present to favor only those molecular interactions required explicitly by the biological function. Electromagnetic messaging among proteins is proposed from the observation that charged amino acids located on the protein surface are mostly in adjacent sequence positions and/or in spatial proximity. Molecular dynamics (MD) simulations have been used to predict electric charge proximities arising from concerted motions of charged amino acid side chains in two protein model systems, human ubiquitin and the chitinolytic enzyme from .
View Article and Find Full Text PDFObjectives: As epilepsy management medical devices emerge as potential technological solutions for prediction and prevention of sudden death in epilepsy (SUDEP), there is a gap in understanding the features and priorities that should be included in the design of these devices. This study aims to bridge the gap between current technology and emerging needs by leveraging insights from persons with epilepsy (PWE) and caregivers (CG) on current epilepsy management devices and understanding how SUDEP awareness influences preferences and design considerations for potential future solutions.
Methods: Two cross-sectional surveys were designed to survey PWE and CG on medical device design features, SUDEP awareness, and participation in medical device research.
Article Synopsis
- There is an increasing demand for effective automated seizure detection algorithms using EEG data due to the rise of long-term monitoring needs.
- This paper introduces a unified framework to standardize validation methods for these algorithms, addressing the inconsistencies in datasets, methodologies, and performance measures.
- The authors also present the EEG 10-20 seizure detection benchmark, along with an open-source software library, to help evaluate existing algorithms and enhance research in seizure detection for better outcomes for individuals with epilepsy.*
Article Synopsis
- * A selection of six branched peptides, designed to improve resistance to proteases and boost efficacy, was tested for antibacterial activity, biofilm inhibition, cytotoxicity, and resistance to breakdown.
- * The peptide BAMP2 demonstrated encouraging results in treating mouse skin infections, suggesting its potential for local application in infection management.
Utilizing plant-based resources, particularly their by-products, aligns with sustainability principles and circular bioeconomy, contributing to environmental preservation. The therapeutic potential of plant extracts is garnering increasing interest, and this study aimed to demonstrate promising outcomes from an extract obtained from an underutilized plant waste. , an invasive macroalga found in the Orbetello Lagoon, thrives in eutrophic conditions, forming persistent mats covering approximately 400 hectares since 2005.
View Article and Find Full Text PDF