The Evolving Role of Genomics in Colorectal Cancer.

Approximately 75% of colorectal cancers (CRCs) harbour an identifiable driver mutation, 5% of which are heritable. These drivers have recognised implications for prognosis and therapy selection. In addition, potential germline mutations require investigations to inform testing of relatives, as well as surveillance for other malignancies.

[No education without feedback: why and how to give it in the clinical setting].

The number of medical students and doctors in training is growing, particularly in private practices due to the promotion of the internal medicine and primary care curriculum. Therefore, doctors increasingly find themselves in a teaching role with the responsibility to give feedback to the people in training. This article aims to give the definition of feedback and to review the reasons for its central role in pre- and postgraduate medical education.

[COPD exacerbation: towards a blood eosinophil-guided corticosteroid therapy?].

Measurement of blood eosinophils helps identify COPD patients at increased risk of acute exacerbation who would benefit from the initiation of maintenance therapy with inhaled corticosteroids. This strategy has been included into the GOLD recommendations. Would there be an interest in measuring blood eosinophils to manage COPD exacerbations? Recently, strategies using blood eosinophil count have been developed to better target the group of patients with exacerbations who respond to systemic corticosteroid therapy and also to limit its prescription when the risk/benefit ratio is unfavorable.

ADHD in children and adolescents: Guideline-based online assessment in the consortium project INTEGRATE-ADHD.

Background: The consortium project INTEGRATE-ADHD compared administrative data on the presence of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with the results of a parent survey and a comprehensive clinical assessment based on the S3 guideline of the Association of the Scientific Medical Societies in Germany (AWMF). Due to the COVID-19 pandemic, the clinical assessment was carried out online.

Methods: The article describes how a guideline-based clinical assessment of ADHD can be implemented in an online setting.