Publications by authors named "A Berkovits"
Proteogenomic analysis in an early onset diffuse gastric cancer patient revealed alterations in PIK3R1, TP53, SMAD4 and a potential role of the PI3K-AKT and EGFR pathways: a case report.
J Gastrointest Oncol
August 2022
Article Synopsis
- Early-onset gastric cancers (EOGC) impact young individuals under 45 and are challenging to treat, often leading to poor outcomes.
- A 26-year-old female patient initially responded to first-line treatment but later progressed; genetic and protein analysis of her tumor revealed numerous mutations and potential therapeutic pathways.
- Despite the presence of biomarkers suggesting better treatment response, standard therapies were ineffective, highlighting the need for innovative approaches to develop more effective treatments for EOGC.
Major advances in sequencing technologies and targeted therapies have accelerated the incorporation of oncology into the era of precision medicine and "biomarker-driven" treatments. However, the impact of this approach on the everyday clinic has yet to be determined. Most precision oncology reports are based on developed countries and usually involve metastatic, hard-to-treat or incurable cancer patients.
View Article and Find Full Text PDFQuality improvement interventions have been shown to improve adherence with bronchiolitis treatment guidelines; however, the long-term effect of these interventions is unclear. We show that while such an intervention led to a long-lasting change, this was attenuated with time. Repeated interventions are required to maintain guideline adherence.
View Article and Find Full Text PDFIntroduction: Diffuse large B-cell lymphoma (DLBCL) is a molecularly heterogeneous disease defined by different cellular origins and mechanisms of oncogenic activation. Approximately 10% of DLBCL cases harbor a MYC rearrangement and this has been associated with a more aggressive clinical course following standard therapy.
Areas Covered: So-called 'double-hit lymphomas' (DHL) or 'triple hit lymphomas' (THL) occur when MYC is concurrently rearranged with BCL2 and/or BCL6.