Publications by authors named "A Berkova"
Background: Lung cancer is one of the leading causes of death worldwide, with incidence and mortality significantly affected by population ageing and changes in the prevalence of risk factors. Lung nodules, which are often detected incidentally on imaging studies, pose a significant diagnostic challenge as they may indicate both benign and malignant processes. Correct diagnosis and management of these nodules is therefore essential to optimize clinical outcomes.
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- Mantle cell lymphoma (MCL) shows recurring genetic changes in key regulators of the phosphoinositol-3-kinase (PI3K) pathway, particularly involving PIK3CA amplifications and PTEN losses.
- In vitro studies using modified MCL cell lines revealed that PIK3CA overexpression reduces reliance on B-cell receptor (BCR) signaling, alters metabolic processes, and leads to therapy resistance without affecting AKT signaling.
- Conversely, PTEN knockout resulted in notable changes, including heightened AKT activation, greater resistance to various inhibitors, and decreased reliance on BCR signaling, indicating how these genetic alterations may promote therapy resistance and adaptive survival mechanisms in MCL.
Background And Objective: Subpleural located pulmonary nodules are perioperatively invisible to the surgeon. Their precise identification is conventionally possible by palpation, but often at the cost of performing a thoracotomy. The aim of the study was to evaluate the success rate and feasibility of the pre-operative CT-guided marking subpleural localized nodule using a mixture of Patent Blue V and an iodine contrast agent prior to the extra-anatomical video-assisted thoracoscopic surgery (VATS) resection in patients for whom the primary anatomical resection in terms of segmentectomy or lobectomy was not indicated.
View Article and Find Full Text PDFBackground: Metastasis to the gallbladder is very rare. This case report highlights a rare cause of acute cholecystitis, which should be considered by the surgeon and other treating physicians in the differential diagnosis of patients with urothelial carcinoma.
Case: We report the case of a 73 year-old man with follow-up oncology care.
At the time of the current COVID-19 pandemic, on a daily basis, we encountered patients suffering from various manifestations of this infection. The most common are respiratory symptoms. Many of the patients require acute hospital care, and a smaller group of them are hospitalized in intensive care units.
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