Publications by authors named "A Berardini"
Background: Electrocardiogram (ECG) has proven to be useful for early detection of cardiac involvement in Anderson-Fabry disease (AFD); however, little evidence is available on the association between ECG alterations and the progression of the disease.
Aim And Methods: To perform a cross sectional comparison of ECG abnormalities throughout different left ventricular hypertrophy (LVH) severity subgroups, providing ECG patterns specific of the progressive AFD stages. 189 AFD patients from a multicenter cohort underwent comprehensive ECG analysis, echocardiography, and clinical evaluation.
Evolution of tricuspid regurgitation after transcatheter edge-to-edge mitral valve repair for secondary mitral regurgitation and its impact on mortality.
Eur J Heart Fail
November 2022
Article Synopsis
- The study aimed to assess how tricuspid regurgitation (TR) changes in the short term after mitral valve repair (M-TEER) in patients with secondary mitral regurgitation (SMR), as well as the factors influencing these changes and their impact on mortality.
- Among 503 SMR patients, 35% showed improvements in TR after M-TEER, while 19% experienced worsening, and 46% remained unchanged; smaller left atrial size and minimal residual mitral regurgitation predicted better TR outcomes.
- Notably, patients who improved their TR had lower all-cause mortality rates over the long term, indicating that achieving TR ≤2+ post-M-TEER significantly reduces mortality risk
Article Synopsis
- RV-PA coupling is important for predicting outcomes in patients with secondary mitral regurgitation (SMR) undergoing transcatheter edge-to-edge mitral valve repair (M-TEER), but its changes post-procedure were previously unclear.
- The study found that 66% of patients showed improvement in RV-PA coupling (measured as TAPSE/PASP) after M-TEER, with several baseline factors predicting this improvement.
- Improved TAPSE/PASP after M-TEER was linked to lower rates of heart failure hospitalization and a decreased risk of long-term mortality, highlighting its prognostic value.
Objectives: To describe a cohort of patients with arrhythmogenic left ventricular cardiomyopathy (ALVC), focusing on the spectrum of the clinical presentations.
Methods: Patients were retrospectively evaluated between January 2012 and June 2020. Diagnosis was based on (1) ≥3 contiguous segments with subepicardial/midwall late gadolinium enhancement in the left ventricle (LV) at cardiac magnetic resonance a likely pathogenic/pathogenic arrhythmogenic cardiomyopathy (AC) associated genetic mutation familial history of AC red flags for ALVC (ie, negative T waves in V4-6/aVL, low voltages in limb leads, right bundle branch block like ventricular tachycardia) or (2) pathology examination of explanted hearts or autoptic cases suffering sudden cardiac death (SCD).
Aims: In patients with heart failure and reduced ejection fraction (HFrEF) and secondary mitral regurgitation (SMR), impaired right ventricular function (RVF) may negatively influence the prognosis. Percutaneous mitral valve repair (pMVR) can promote the recovery of RVF. We sought to characterize the response of the right ventricle to pMVR in HFrEF with SMR and to assess the association between improved RVF after pMVR and outcomes.
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