Crystal structure, DFT calculations and Hirshfeld surface analysis of 3-(4-methyl-phen-yl)-6-nitro-1-indazole.

The asymmetric unit of the title compound, CHNO, consists of two independent mol-ecules having very similar conformations in which the indazole moieties are planar. The independent mol-ecules are distinguished by small differences in the rotational orientations of the nitro groups. In the crystal, N-H⋯O and C-H⋯O hydrogen bonds form zigzag chains along the -axis direction.

[Backup territorial coordination, nursing roles and skills].

Backup territorial coordination provides accompaniment and support for professionals who work with the fragile elderly people in an area. It aligns the sanitary, medical-social and social approaches, and mobilizes useful resources to optimize the treatment pathway. It has been implemented in the Nancy urban area by an operational team including nurses and a geriatric physician.

[Experimentation of an e-platform to detect situations at risk of cardiac impairment (platform E-care) in an internal medicine unit].

Introduction: Monitoring patients with heart failure by telemedicine systems is a potential means susceptible to optimize the management of these patients and avoid life-threatening emergencies. In this context, we experimented in internal medicine unit an e-platform E-care dedicated to automated, intelligent detection of situations at risk of heart failure.

Methods: The E-care platform based on medical sensors (blood pressure, heart rate, O2, weight), communicating (Bluetooth), to go up, in real time, to an intelligent physiological information and an analysis of the ontology medical, leading ultimately to the generation of alerts.

[Susceptibility genes, HLA and diabetic retinopathy in the Algerian population].

Background: Diabetic retinopathy (DR) is the most frequent microvascular complication of type I diabetes (T1D). Some well-controlled type I diabetics may develop DR, while other poorly-controlled diabetics do not develop DR. This might be explained by certain susceptibility genes or protective genes.