Cervical insufficiency a prologue for future pelvic organ prolapse?

Background: Preliminary evidence suggests that women with cervical oss insufficiency may have an increased risk to develop pelvic organ prolapse later in life, suggesting a common underlying collagen-oriented mechanism.

Objective: The objective of this study was to determine the association between cervical oss insufficiency and the subsequent development of pelvic organ prolapse.

Study Design: A matched, case-control study, including women who delivered at the Soroka University Medical Center.

Bronchial or Pulmonary Artery Chemoembolization for Unresectable and Unablatable Lung Metastases: A Phase I Clinical Trial.

Background Lung chemoembolization is an emerging treatment option for lung tumors, but the optimal embolic, drug, and technique are unknown. Purpose To determine the technical success rate and safety of bronchial or pulmonary artery chemoembolization of lung metastases using ethiodized oil, mitomycin, and microspheres. Materials and Methods Patients with unresectable and unablatable lung, endobronchial, or mediastinal metastases, who failed systemic chemotherapy, were enrolled in this prospective, single-center, single-arm, phase I clinical trial (December 2019-September 2020).

Radiation segmentectomy of hepatic metastases with Y-90 glass microspheres.

Purpose: To evaluate safety and efficacy of radiation segmentectomy (RS) with Y glass microspheres in patients with limited metastatic liver disease not amenable to resection or percutaneous ablation.

Methods: Patients with ≤ 3 tumors treated with RS from 6/2015 to 12/2017 were included. Target tumor radiation dose was > 190 Gy based on medical internal radiation dose (MIRD) dosimetry.

Transarterial Embolization of Liver Cancer in a Transgenic Pig Model.

Purpose: To develop and characterize a porcine model of liver cancer that could be used to test new locoregional therapies.

Materials And Methods: Liver tumors were induced in 18 Oncopigs (transgenic pigs with Cre-inducible TP53 and KRAS mutations) by using an adenoviral vector encoding the Cre-recombinase gene. The resulting 60 tumors were characterized on multiphase contrast-enhanced CT, angiography, perfusion, micro-CT, and necropsy.

Re-Appraisal of Echocardiographic Assessment in Patients with Pulmonary Embolism: Prospective Blinded Long-Term Follow-Up.

Background: Acute pulmonary embolism (PE) is considered to be one of the most common cardiovascular diseases with considerable mortality. Conflicting data imply possible role for echocardiography in assessing this disease.

Objectives: To determine which of the echo parameters best predicts short-term and long-term mortality in patients with PE.