Brainstem serotonin amplifies nociceptive transmission in a mouse model of Parkinson's disease.

Parkinson's disease arises from the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as akinesia, rigidity, and tremor at rest. The non-motor component of Parkinson's disease includes increased neuropathic pain, the prevalence of which is 4 to 5 times higher than the general rate. By studying a mouse model of Parkinson's disease induced by 6-hydroxydopamine, we assessed the impact of dopamine depletion on pain modulation.

Towards decarbonizing large-scale industries: A decision support framework for optimizing grid-connected PV-battery energy systems planning - Case study of an OCP mining site, Morocco, North Africa.

Incorporating renewable energy into forthcoming grid-connected or decentralized energy systems assumes an escalating significance and can potentially enhance endeavors toward accomplishing Sustainable Development Goal 7 (SDG7). Nevertheless, deploying sustainable renewable energy-intensive systems may present challenges related to their intermittency and cost instability. This paper proposes the development of a decision support model aimed at planning an optimal on-grid PV battery system.

Modulating Neural Circuits of Pain in Preclinical Models: Recent Insights for Future Therapeutics.

Chronic pain is a pathological state defined as daily pain sensation over three consecutive months. It affects up to 30% of the general population. Although significant research efforts have been made in the past 30 years, only a few and relatively low effective molecules have emerged to treat chronic pain, with a considerable translational failure rate.

Interplay between subthalamic nucleus and spinal cord controls parkinsonian nociceptive disorders.

Pain is a non-motor symptom that impairs quality of life in patients with Parkinson's disease. Pathological nociceptive hypersensitivity in patients could be due to changes in the processing of somatosensory information at the level of the basal ganglia, including the subthalamic nucleus (STN), but the underlying mechanisms are not yet defined. Here, we investigated the interaction between the STN and the dorsal horn of the spinal cord (DHSC), by first examining the nature of STN neurons that respond to peripheral nociceptive stimulation and the nature of their responses under normal and pathological conditions.

Usefulness of thalamic beta activity for closed-loop therapy in essential tremor.

A partial loss of effectiveness of deep brain stimulation of the ventral intermediate nucleus of the thalamus (VIM) has been reported in some patients with essential tremor (ET), possibly due to habituation to permanent stimulation. This study focused on the evolution of VIM local-field potentials (LFPs) data over time to assess the long-term feasibility of closed-loop therapy based on thalamic activity. We performed recordings of thalamic LFPs in 10 patients with severe ET using the ACTIVA™ PC + S (Medtronic plc.