Publications by authors named "A Ben Slama"
Background: Whole lung transpulmonary chemoembolization using a combination of doxorubicin (DXO) and degradable starch microspheres (DSM-TPCE) might be a promising treatment option in soft tissue sarcoma. To pave the way for clinical studies, this study aimed to evaluate the short-term effects of DSM-TPCE with DXO using an ex vivo isolated lung perfusion (ILP) model.
Methods: Nine lung specimens retrieved from patients undergoing lobectomy underwent ex vivo ILP.
Article Synopsis
- Thiopurine drugs are used to treat conditions like inflammatory bowel disease, and their metabolism is influenced by the enzymes TPMT and ITPA.
- This study focuses on Tunisian patients to assess how genetic factors and other variables affect the pharmacokinetics of thiopurine drugs.
- The research found specific genetic variants and identified gender as a significant factor affecting drug variability, emphasizing the importance of TPMT testing for optimal treatment safety and efficacy.
Bilateral lung volume reduction surgery outperforms the unilateral approach in functional improvement.
Interdiscip Cardiovasc Thorac Surg
October 2024
Objectives: Lung volume reduction surgery (LVRS) is an established treatment approach for patients with severe pulmonary emphysema, enhancing lung function and quality of life in selected patients. Functional benefits and outcomes after uni- versus bilateral lung volume reduction remain a topic of debate.
Methods: A retrospective analysis of patients undergoing LVRS from January 2018 to October 2022 was conducted.
This article aims to analyze a stochastic epidemic model (Susceptible-exposed-undetected infected-detected infected (reported -recovered) assuming that the transmission rate at which people undetected become detected is perturbed by the Ornstein-Uhlenbeck process. Our first objective is to prove that the stochastic model has a unique positive global solution by constructing a nonnegative Lyapunov function. Afterward, we provide a sufficient criterion to prove the existence of an ergodic stationary distribution of the mode by constructing a suitable series of Lyapunov functions.
View Article and Find Full Text PDFBackground: There is a growing demand for colonoscopy, worldwide, resulting in increased rate of inappropriate referrals. This "overuse" of colonoscopies has become a major burden for health care.
Objectives: to assess the appropriateness of colonoscopies performed at the endoscopy unit of the university hospital of Sousse and to compare these results of appropriateness according to the European Panel of Appropriateness of Gastrointestinal Endoscopy (EPAGE) I and EPAGE II criteria.