Publications by authors named "A Bello-Klein"
This study explored the effects of melatonin on cardiac and vascular function, and redox homeostasis in model PAH. Male Wistar rats were divided into: control (CTR), monocrotaline [MCT (60 mg/kg, single dose i.p)], monocrotaline + sildenafil [MCT + SIL (50 mg/kg/day)], and monocrotaline + melatonin [MCT + MEL (10 mg/kg/day)].
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- Sustained adrenergic overload can lead to harmful changes in the heart, characterized by oxidative stress, which can worsen heart function.
- Boldine (BOL), an antioxidant, was tested for its potential to protect the heart from damage caused by isoproterenol (ISO) in a rat study.
- Results showed that BOL significantly reduced heart enlargement and improved oxidative stress markers compared to ISO alone, suggesting it could be a beneficial treatment for adverse cardiac changes.
Adrenergic overstimulation is detrimental to the left ventricle. However, its effects on the right ventricle (RV) are not clear. Since adrenergic overload increases metabolic demand and oxidative stress, boldine could be a therapeutic option in the treatment of cardiovascular disease due to its antioxidant role.
View Article and Find Full Text PDFThis study explored the association of cardioprotective role of thyroid hormones (TH) and benefit effects of grape juice (GJ) on vascular function against the apoptosis and inflammation associated with monocrotaline (MCT)-induced pulmonary hypertension (PH). Wistar rats were distributed into five groups: control; PH (MCT 60mg/kg i.p.
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- Preterm individuals are at higher risk for heart disease due to changes in cardiac autonomic function, which can be influenced by factors during early development.
- A study on rats showed that exposure to high oxygen levels (hyperoxia) in early life alters blood pressure patterns and heart rate variability, linked to the activation of a specific receptor (AT1).
- Blocking the AT1 receptor with losartan mitigated some of these changes, highlighting the role of the renin-angiotensin system in altering cardiac function due to neonatal conditions.