Publications by authors named "A Belin"
Article Synopsis
- The study explores how copy number variations (CNVs) affect the development of Parkinson's disease (PD), aiming to identify new genetic mechanisms linked to sporadic cases of the disease.
- Utilizing data from over 11,000 PD patients and nearly 9,000 controls, the researchers discovered 14 significant CNV loci associated with PD, including various gene duplications and deletions.
- The research highlights a higher prevalence of CNVs in specific PD-related genes among patients and suggests that certain CNVs, especially those involving the gene, may lead to earlier onset of the disease in early-onset PD cases.
Article Synopsis
- Cluster headache involves pain signaling linked to inflammation in the trigeminovascular pathway, prompting a study of inflammatory markers in affected patients versus controls.
- A case-control study analyzed cerebrospinal fluid and serum from various groups of cluster headache patients to explore changes in inflammatory cytokine levels.
- The results indicated increased cytokine levels in the cerebrospinal fluid of cluster headache patients, suggesting ongoing neuroinflammation, which appears consistent regardless of the phase of the headache.
Article Synopsis
- The study investigates the relationship between body mass index (BMI) and Parkinson's disease (PD) using a method called Mendelian randomization to determine if higher genetically predicted BMI is linked to a lower incidence of PD.
- Researchers analyzed genetic data from large groups of individuals, including over 800,000 for BMI and nearly 29,000 for PD, focusing on factors like age, disease duration, and gender to examine the associations.
- Results indicated an inverse relationship between genetically predicted BMI and PD, particularly among younger participants and women, suggesting that lower BMI may be associated with a higher risk of developing Parkinson's disease.
Article Synopsis
- Cluster headache is a severe type of headache marked by intense pain on one side of the head and accompanying symptoms, with its underlying causes still not completely understood.
- Recent research has led to better treatment options and a deeper grasp of the condition, highlighting both similarities and regional differences in how it's experienced around the world.
- New therapies, such as galcanezumab targeting CGRP, have been approved in the US but face limitations in Europe, emphasizing the need for ongoing global collaboration for improved understanding and treatment development.
The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface receptor, was strongly associated with cluster headache through genetic studies. Further, the MERTK ligand galectin-3 has been found to be elevated in serum of migraine patients.
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