A review of chitosan polysaccharides: Neuropharmacological implications and tissue regeneration.

One of the current challenges in targeting neurological disorders is that many therapeutic molecules cannot cross the blood-brain barrier (BBB), which limits the use of natural molecules in nervous tissue regeneration. Thus, the development of new drugs to effectively treat neurological disorders would be a challenge. Natural resources are well known as a source of several therapeutic agents for the treatment of neurologic disorders.

Changes in Practices After Implementation of a Patient Blood Management Program in French Surgical Departments: The National Multicenter Observational PERIOPES Study.

Background: Patient blood management (PBM) is an evidence-based approach recommended to improve patient outcomes. Change in practices is often challenging. We report here data from French surgical departments before and after a standardized implementation of a PBM program.

Severe Postoperative Pain in Total Knee Arthroplasty Patients: Risk Factors, Insights and Implications for Pain Management via a Digital Health Approach.

Up to 25% of patients undergoing knee arthroplasty report chronic pain postoperatively. Early identification of high-risk individuals can enhance pain management strategies. This retrospective analysis investigates the incidence of severe postoperative pain and its associated risk factors among 740 patients who underwent total knee arthroplasty.

Buckling and Free Vibration Analyses of Various Nanoparticle Reinforced Concrete Beams Resting on Multi-Parameter Elastic Foundations.

Given their considerable specific surface area and amorphous characteristics, nanoparticles exhibit excellent pozzolanic activity, and when undergoing a reaction with calcium hydroxide, this leads to the generation of a denser matrix by promoting the formation of a greater amount of C-S-H gel, thereby enhancing the strength and durability of the concrete and fortifying the overall structure. Indeed, the present study investigates a comparative study of the buckling and free vibration analyses of concrete beams reinforced with various types of nanoparticles. For its simplicity and accuracy, a higher-order shear deformation theory will be used to analytically model the reinforced concrete beam.