Publications by authors named "A Bekker"
The majority of large iron formations (IFs) were deposited leading up to Earth's great oxidation episode (GOE). Following the GOE, IF deposition decreased for almost 500 Myr. Subsequently, around 1.
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- * The study involved 23,748 neonates and found a HA-BSI rate of 2.0 per 1000 patient days, with the highest rates in very low birth weight infants and high mortality (31.8%) associated with infections, particularly in preterm and those with Gram-negative/fungal infections.
- * Empiric antibiotic coverage varied by hospital, averaging 66-92%, but concerns were raised about increasing carbapenem resistance, highlighting the need for regular updates to treatment protocols.
Despite advances in human immunodeficiency virus (HIV) prevention, new pediatric HIV infections continue, necessitating optimized and simplified antiretroviral treatment (ART) regimens tailored for children. Advances in treatment options have been made possible by the availability of child-friendly fixed-dose formulations with decreased dosing frequency, especially in low- and middle-income countries. Ongoing work to improve ART options for neonates and supporting the shift toward long-acting ART for children and adolescents remains a priority.
View Article and Find Full Text PDFTreatment options for children living with HIV have historically been less effective, less practical and more difficult to implement compared with those for adults, as the research and development of new drugs for children has lagged behind. Significant progress has been achieved in response to the paediatric HIV epidemic over the last decade. Several optimised paediatric antiretroviral formulations are currently available or in development, including fixed-dose combination tablets containing a complete World Health Organization-recommended regimen.
View Article and Find Full Text PDFBackground And Objectives: Neonatal mortality due to severe bacterial infections is a pressing global issue, especially in low-middle-income countries (LMICs) with constrained healthcare resources. This study aims to validate the Neonatal Healthcare-associated infectiOn Prediction (NeoHoP) score, designed for LMICs, across diverse neonatal populations.
Methods: Prospective data from three South African neonatal units in the Neonatal Sepsis Observational (NeoOBS) study were analysed.