Psychodynamic and sociopolitical predictors of COVID Distress and Gravity.

This study examined the relationship between attachment style and fear of contamination during the COVID-19 pandemic, hypothesizing that anxiously attached participants would be more distressed when their safe space was threatened by someone leaving and returning. During May 2020,  = 355 participants provided demographics, personality, health anxiety scores, attachment styles, political ideology, and attitudes towards the pandemic. In both social media and MTurk subsamples (but not in a subsample from a ListServ of professional psychologists), anxious attachment was a significant predictor of distress above and beyond personality and health anxiety.

Adjuvant Ipilimumab in High-Risk Uveal Melanoma.

Uveal melanoma is a common intraocular malignant tumor that is uniformly fatal once metastatic. No effective adjuvant therapy currently exists to reduce the risk of distant metastasis after definitive treatment of the primary lesion. Immunotherapy has been used effectively in the adjuvant setting in locally advanced cutaneous melanoma.

Phase I/II Study of Hepatic Arterial Infusion of Nab-paclitaxel in Patients With Metastatic Melanoma to the Liver.

Objectives: Hepatic arterial infusion (HAI) of cytotoxic chemotherapy is a strategy to deliver high dose of anticancer therapy to liver metastases that derive their blood supply from the hepatic artery. Metastatic melanoma (MM) has a high incidence of liver metastases, with uveal subtype in particular exhibiting a predilection for liver dissemination. Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) has demonstrated efficacy in MM and first-pass hepatic metabolism.

A phase II study of ipilimumab plus temozolomide in patients with metastatic melanoma.

Checkpoint blockade has revolutionized the treatment of melanoma; however, it benefits only the minority of patients. Several agents have been combined with immunotherapy to improve T-cell activation and persistence including growth factor, chemotherapy, and radiation. Preclinical data suggest that temozolomide, which metabolizes to the same active compound as dacarbazine, selectively depletes regulatory T cells.

A phase I study of TPI 287 in combination with temozolomide for patients with metastatic melanoma.

TPI 287 is a synthetic taxane derivative with structural modifications allowing for central nervous system penetration and potential circumvention of multidrug resistance efflux pump mechanisms. The aim of this phase I study was to determine the maximum tolerated dose of the combination of TPI 287 and temozolomide in metastatic melanoma. Patients with stage IV unresectable or recurrent stage III melanoma were eligible.