Publications by authors named "A Beaudin"
During embryogenesis, cells arrange into precise patterns that enable tissues and organs to develop specialized functions. Despite its critical importance, the molecular choreography behind these collective cellular behaviors remains elusive, posing a major challenge in developmental biology and limiting advances in regenerative medicine. By using the mouse hair follicle as a mini-organ system to study the formation of bud-like structures during embryonic development, our work uncovers a crucial role for the Rho GTPase regulator ARHGEF3 in hair follicle morphogenesis.
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- - Cerebral amyloid angiopathy (CAA) leads to gait impairments, but the relationship between these impairments and brain structure is not well understood.
- - The study assessed participants with CAA, Alzheimer's disease (AD), and normal controls, measuring gait performance along with brain white matter and grey matter characteristics.
- - Findings indicated that reduced white matter integrity and grey matter atrophy are linked to poorer gait performance across all groups, highlighting significant neurological factors that contribute to gait issues in CAA and AD.
Article Synopsis
- Obstructive sleep apnea (OSA) has been linked to an increased risk of cognitive impairment, and EEG sleep microarchitecture measures could help identify at-risk individuals.
- A study with 1,142 suspected OSA patients assessed various cognitive functions and analyzed associations between cognitive scores and specific EEG characteristics during sleep, finding that spindle density and normalized EEG power were significantly lower in those with moderate to severe OSA.
- The research concluded that changes in spindle activity and EEG measures might play a critical role in understanding cognitive deficits experienced by OSA patients.
Here, we examine how prenatal inflammation shapes tissue function and immunity in the lung by reprogramming tissue-resident immune cells from early development. Maternal, but not fetal, type I interferon-mediated inflammation provokes expansion and hyperactivation of group 2 innate lymphoid cells (ILC2s) seeding the developing lung. Hyperactivated ILC2s produce increased IL-5 and IL-13 and are associated with acute Th2 bias, decreased Tregs, and persistent lung eosinophilia into adulthood.
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