ASSESSMENT OF OPHTHALMIC DIAGNOSTIC PARAMETERS, CONJUNCTIVAL FLORA, AND PHARMACOLOGIC DILATION OF A LARGE POPULATION OF JUVENILE AMERICAN ALLIGATORS ().

American alligators () are an important apex predator of semiaquatic habitats of the southern United States. Commercial alligator farming has grown in the last several decades, leading to a need to understand the health conditions that affect this species to ensure appropriate management and welfare. The aims of this study were 1) to establish and describe normative data including results of common ophthalmic diagnostic tests and conjunctival flora, 2) document ocular pathology in this population, and 3) assess the effect of topical rocuronium bromide and 10% phenylephrine for facilitating pharmacologic mydriasis.

Deep-Red and Near-Infrared Compact Cyanine Dyes for Sensitive NAD(P)H Sensing in Live Cells and Kidney Disease Tissues.

Cyanine dyes constructed for NAD(P)H near-infrared sensing utilize extended π-conjugation but often exhibit delayed fluorescence responses to NAD(P)H due to reduced positive charge density in 3-quinolinium acceptors. This study introduces deep-red and near-infrared compact cyanine dyes represented by probes and for mitochondrial NAD(P)H detection in live cells. Probes and feature a unique structural design with a double bond connection linking 3-quinolinium to strategically positioned 1-methylquinolinium acceptor units at 2- and 4-positions, correspondingly.

Comparative analysis of meningeal transcriptomes in birds: Potential pathways of resilience to repeated impacts.

The meninges and associated vasculature (MAV) play a crucial role in maintaining cerebral integrity and homeostasis. Recent advances in transcriptomic analysis have illuminated the significance of the MAV in understanding the complex physiological interactions at the interface between the skull and the brain after exposure to mechanical stress. To investigate how physiological responses may confer resilience against repetitive mechanical stress, we performed the first transcriptomic analysis of avian MAV tissues using the Downy Woodpecker (Dryobates pubescens) and Tufted Titmouse (Baeolophus bicolor) as the comparison species.

Understanding activity and physiology at scale: The Apple Heart & Movement Study.

Physical activity or structured exercise is beneficial in a wide range of circumstances. Nevertheless, individual-level data on differential responses to various types of activity are not yet sufficient in scale, duration or level of annotation to understand the mechanisms of discrete outcomes nor to support personalized recommendations. The Apple Heart & Movement Study was designed to passively collect the dense physiologic data accessible on Apple Watch and iPhone from a large real-world cohort distributed across the US in order to address these knowledge gaps.