Publications by authors named "A Bea"
Article Synopsis
- Recent studies indicate that high levels of high-density lipoprotein cholesterol (HDLc) may paradoxically increase the risk of mortality, prompting an investigation into its association with death in individuals with high cholesterol.
- A study of 2,992 subjects with primary hypercholesterolemia tracked mortality over an average of 10.2 years, revealing that those with low HDLc had a significantly higher risk of death compared to those with high HDLc.
- Despite these findings, when accounting for other major cardiovascular risk factors, HDLc levels were not independently linked to total, cardiovascular, or non-cardiovascular mortality.
Differences in immune response between men and women may influence the outcome of infectious diseases. Intestinal infection with Entamoeba histolytica leads to hepatic amebiasis, which is more common in males. Previously, we reported that innate immune cells contribute to liver damage in males in the murine model for hepatic amebiasis.
View Article and Find Full Text PDFInfluence of triglyceride concentration in lipoprotein (a) as a function of dyslipidemia.
Clin Investig Arterioscler
March 2024
Article Synopsis
- Recent research indicates an inverse correlation between lipoprotein(a) [Lp(a)] and triglycerides (TG) levels, particularly in individuals without diabetes or obesity.
- In a study of over 5,000 patients, Lp(a) concentrations were found to be significantly lower when TG levels exceeded 300 mg/dL, with the lowest levels occurring in those with TG over 1000 mg/dL.
- The findings suggest that the relationship between Lp(a) and TG varies based on the presence of factors like diabetes and obesity, highlighting a need for further research into the underlying mechanisms of this association.
Background: APOE gene encoded a multifunctional protein in lipid metabolism, also associated with inflammatory markers. Type 2 diabetes (T2D) is a complex metabolic disease related to increased blood glucose, triglycerides and VLDL and associated with different dyslipidaemias. The aim of this study was to analyze whether the APOE genotype could determining the risk of developing T2D in a large cohort of workers.
View Article and Find Full Text PDFBackground: apo (apolipoprotein) E has crucial role in lipid metabolism. The genetic variation in gene is associated with monogenic disorders and contributes to polygenic hypercholesterolemia and to interindividual variability in cholesterol. rare variants may be involved in the phenotype of genetic hyperlipidemias.
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