Publications by authors named "A Bayer"
Background: Methicillin-resistant Staphylococcus aureus (MRSA) are resistant to nearly all β-lactam antibiotics under standard testing conditions. However, a novel phenotype exists wherein certain MRSA strains exhibit β-lactam susceptibility in the presence of bicarbonate (termed 'NaHCO3-responsive'), an abundant ion in mammalian tissues and blood. This suggests that specific MRSA infections may be treatable by β-lactams.
View Article and Find Full Text PDFObjectives: The objective of this study is to assess the frequency of the novel sodium bicarbonate (NaHCO)-responsive phenotype, wherein clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates are rendered susceptible to standard-of-care β-lactams in the presence of NaHCO, in a collection of 103 clinical U.S. MRSA skin and soft-tissue infection (SSTI) isolates and 22 clinical European SSTI isolates.
View Article and Find Full Text PDFTargeted temperature management (TTM) with therapeutic hypothermia (TH) during aortic arch surgery requires valid estimations of core body temperature. The ear canal and epitympanic region might be an easy-to-assess, noninvasive site for the read-out of supra-aortic, cerebral temperature. This observational cohort study comparatively investigated in-ear temperature and different core body temperature (cBT) measurements during TTM/TH for moderate hypothermic circulatory arrest (mHCA) in aortic arch surgery.
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- Daptomycin (DAP) is an antibiotic used to treat drug-resistant infections like MRSA, but resistance to DAP is becoming more common and occurs through various mechanisms.
- This study examines how DAP resistance affects the sensitivity to the phage Sb-1 in 14 clinical MRSA strains, finding that resistant strains are more susceptible to the phage.
- Results show that DAP-resistant mutant strains have increased phage sensitivity and differences in their cell wall structure compared to DAP-susceptible strains, suggesting that using phages alongside DAP could be an effective way to combat resistance.*
Bicarbonate and CO are essential substrates for carboxylation reactions in bacterial central metabolism. In , the bicarbonate transporter, MpsABC (membrane potential-generating system) is the only carbon concentrating system. An deletion mutant can hardly grow in ambient air.
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