Publications by authors named "A Baskan"
Background: Cystic fibrosis (CF) is a multisystemic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective synthesis or function of the CFTR protein. Historically, CF treatment focused on managing symptoms and complications. Fortunately, modulator drugs are now available to directly target the defective CFTR protein.
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- The study analyzes data from the CF Registry of Turkey to measure the rate of decline in pulmonary function (ppFEV1) among cystic fibrosis patients and identifies risk factors related to this decline.
- It found that patients with more severe disease (ppFEV1 < 40) had poorer nutritional status and a higher prevalence of chronic Pseudomonas aeruginosa infection compared to those with better lung function.
- The results emphasize the need for regular monitoring of patients with normal initial ppFEV1 and early treatment for P. aeruginosa infections, highlighting the crucial role of proper nutrition in managing cystic fibrosis.
Introduction: Cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs target the underlying defect and improve CFTR function. They are a part of standard care in many countries, but not all patients are eligible for these drugs due to age and genotype. Here, we aimed to determine the characteristics of non-eligible patients for CFTR modulators in the CF registry of Turkey (CFRT) to highlight their clinical needs.
View Article and Find Full Text PDFUnlabelled: BACKGROUND AND OBJECTIVES: Children with tracheostomies are at increased risk of tracheostomy-related complications and require extra care. Standardized training programs for caregivers can improve tracheostomy care and reduce complications. In this study, we compared caregiver knowledge and skill scores after a standardized theoretical and practical training program on tracheostomy care (IStanbul PAediatric Tracheostomy (ISPAT) project) immediately and 1 year post-training and evaluated how this training affected the children's clinical outcomes.
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