Publications by authors named "A Basire"
HLA-A*23:147 differs from HLA-A*23:13 allele by one nucleotide substitution in codon 283 in exon 5.
View Article and Find Full Text PDFAllogeneic stem cell transplantation (Allo-SCT) is the only rapidly available curative treatment modality in patients with severe sickle cell disease (SCD). The development of reduced-toxicity myeloablative conditioning (RT-MAC) regimen and the use of partially matched family donors with post-transplantation cyclophosphamide (PT-Cy) have widened the access to Allo-SCT. Antibodies against donor-specific HLA (DSA) increase the risk of engraftment failure in HLA mismatched Allo-SCT.
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- Lung transplantation often faces challenges due to acute or chronic rejection, linked to the presence of HLA donor-specific antibodies and other autoantibodies.
- Non-classical HLA molecules, such as HLA-G, play a role in immune acceptance of lung grafts; certain isoforms are associated with poorer outcomes in transplants.
- The study aimed to investigate HLA-G antibody prevalence in lung transplant recipients, finding specific antibody reactivity rare, with non-specific responses indicating possible issues with autoantigens in the testing cells.
In an ineffective transfusion context, solid-phase immunoassays using the Luminex platform for the detection and characterization of HLA antibodies are currently used to select HLA-compatible platelet products. A new HLA antibody identification method, the HISTO SPOT® HLA AB test (BAG Health care GmbH, Lich, Germany), based on the detection of antibodies directed against a recombinant single antigen (SA) by colored spots detected by HISTO MATCH HLA AB module software, runs fully automated on the MR.SPOT®.
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- HLA-B*07:482 is a variant of the HLA-B*07:02:01:01 allele.
- The difference between the two alleles is due to a single nucleotide change.
- This change occurs specifically in codon 285 of exon 5.