[Rheologic properties of some pharmaceutical excipients in drug forms and cosmetic preparation technology].

The establishment of mechanisms and principles of the formation of deformation (fracture) of spatial structure of bentonite solutions and various solutions and disperse systems is one or the most important problems of modern pharmaceutical technology. The article presents the results of a long-term research of influence of high-molecular compounds and surfactants on the properties of designed dosage drug forms and cosmetic preparation. Research data, as the basis for drug combinations "gel" with dekamitoksin, extract Aesculus hippocastanum L and probiotics.

Microbe contamination of the cream with the dense extract of walnut leafs during storage.

As a result of experiment there has been studied microbial contamination of cream with a dense extract of leaves of a walnut, which is intended for dry skin care, inclined to irritation in process of storage during two years at the following temperature modes: 4,0+/-2,0 degrees C and 25,0+/-2,0 degrees C. There is experimentally proved, that in developed cream with a dense extract of leaves of a walnut, during the entire storage period, there have not been revealed presence of bacterium of family Enterobacteriaceae, Staphylococcus aureus, Pseudomonas aeruginosa. There is established microbiological cleanliness, have been defined, that the total number of bacterium for 1 g of preparation does not exceed 10, and the same of fungus - 20.

The study of horse chestnut leaf parameters.

In order to prepare the new remedy--the tincture of leafs of horse-chestnut, we studied technological parameters of the vegetal material. With the purpose of definition of optimal conditions of extraction of operating substance from vegetative raw materials, calculation of norm of raw material charge and extractive by development technological regulations, and also for management for process of extracting have been studied some technological properties of horse-chestnut. In the course of experimental works, there were specified relative density, bulk weight and volume weight; porosity, free volume of a layer of a raw material, rate of water absorption.