Publications by authors named "A Bartke"
Article Synopsis
- Aging leads to a decline in thermoregulation, lowering core body temperature (Tc), which, while being a marker of healthy aging, negatively affects cognitive function in Alzheimer's disease models.
- The study tested whether increasing Tc through thermotherapy could enhance metabolism and cognitive performance in APP/PS1 mice by exposing them to higher temperatures (30°C) compared to standard conditions (23°C) from 6 to 12 months of age.
- Results showed improved glucose tolerance and insulin sensitivity in mice exposed to higher temperatures, with varying effects based on sex; while male mice benefited cognitively, female APP/PS1 mice experienced worsened spatial memory, highlighting the need for more research on thermotherapy's potential
Article Synopsis
- * Lifespan studies of male and female AD mouse models show significant differences in survival rates based on sex and genetic background.
- * The findings highlight the importance of including both sexes in research to better understand and treat Alzheimer's disease.
Article Synopsis
- Lifespans in mammals can differ significantly, with developmental speed being inversely related to lifespan, suggesting early-life interventions (ELIs) could modify aging patterns.
- This review examines how various postnatal interventions in mice, such as diet changes and chemical treatments, impact development and lifespan, highlighting significant changes in aging processes.
- Understanding the complexities of ELI research requires careful experimental design and attention to factors like timing and sex differences, which can inform future strategies for promoting healthy aging.
Senescent cells accumulate throughout the body and brain contributing to unhealthy aging and Alzheimer's disease (AD). The APP amyloidogenic AD mouse model exhibits increased markers of senescent cells and the senescence-associated secretory phenotype (SASP) in visceral white adipose tissue and the hippocampus before plaque accumulation and cognitive decline. We hypothesized that senolytic intervention would alleviate cellular senescence thereby improving spatial memory in APP mice.
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