Publications by authors named "A Barr"

Stress wave dispersion can result in the loss or distortion of critical high-frequency data during high-strain-rate material tests or blast loading experiments. The purpose of this work is to demonstrate the benefits of correcting stress wave dispersion in split-Hopkinson pressure bar experiments under various testing situations. To do this, an innovative computational algorithm, SHPB_Processing.

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High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

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Background: Fireworks are known to cause severe ocular injuries. This study was intended to examine the pattern and visual outcomes of firework-related severe eye injuries in Malaysia.  Methods: A retrospective review of fireworks-related eye injuries was conducted in Malaysia from 1 July 2022 to 30 June 2023.

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Background: Quiescence is reversible proliferative arrest. Multiple mechanisms regulate quiescence that are not fully understood. High expression of the CDK inhibitor p21 correlates with a poor prognosis in non-small cell lung cancer (NSCLC) and, in non-transformed cells, p21 promotes quiescence after replication stress.

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Article Synopsis
  • Sodium/glucose cotransporter 2 inhibitors (SGLT2is), such as empagliflozin, show potential heart protection benefits in individuals with or without diabetes and can inhibit a key cardiac sodium current linked to congenital long QT syndrome type 3 (LQT3).
  • Researchers used the whole-cell patch-clamp technique to study how empagliflozin affects late sodium current (late I) in various LQT3 mutations of the Nav1.5 channel.
  • Empagliflozin specifically inhibited late I in certain mutations without altering channel kinetics, suggesting it could be an effective targeted treatment for patients with LQT3 mutations in the inactivation gate area.
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