Publications by authors named "A Barfield"
Background: COVID-19 stay-at-home orders and research restrictions halted recruitment and follow-up of clinical research patients. Although clinical research has resumed, it is an open question whether research participation has returned to levels similar to those before COVID-19.
Methods: We used data from the TECH-PN (NCT No.
Article Synopsis
- Mesenchymal stromal cells (MSCs) grown as high-density sheets show potential for bioengineering, but prolonged culture leads to rapid aging, limiting their effectiveness.
- This study investigated the effects of rapamycin on placental-derived MSCs (PMSCs) treated over 7 days, revealing that it enhances autophagy, reduces senescence, and lowers cell size and apoptosis rates.
- Microarray analysis confirmed changes in gene expression, highlighting the upregulation of IL-8 and TGF-β signaling pathways, indicating that rapamycin could improve the healing properties of these cells in future bioengineering applications.
Background: Increasing the percentage of people living with human immunodeficiency virus (HIV), including youth, who are virally suppressed to 95% is an overall goal of the ending the HIV epidemic initiative. While patient portals have become ubiquitous, questions remain about how best to operationalize parental/guardian access to youth's patient portals in alignment with optimizing HIV care outcomes and patient preferences. This qualitative study focuses on understanding perspectives among youth with HIV (YHIV) about parental access to patient portals.
View Article and Find Full Text PDFPurpose: We sought to describe the relationship between COVID-19 risk perception and sexual behaviors among urban adolescents and young adults (AYA).
Methods: Data were collected from 159 urban AYAs on COVID-19 risk perception, COVID-19 infections and deaths, romantic relationships, and sexual behavior during the stay-at-home order using a telephone survey.
Results: Seventy-nine percent of the study participants engaged in sexual intercourse during the stay-at-home order.
Article Synopsis
- Skeletal tissue healing involves a complex mechanism, and while it's known that reactive oxygen species (ROS) are generally harmful, they also play a crucial positive role in fracture healing.
- High ROS levels can hinder normal healing processes and lead to nonunion fractures, highlighting the need for a balanced approach.
- The review explores how ROS affects signaling pathways, angiogenesis, and osteogenic differentiation, and discusses current methods to control ROS for better skeletal tissue healing, aiming to inspire new techniques for tissue regeneration.