Publications by authors named "A Baptista"
Article Synopsis
- Current guidelines suggest high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) should undergo early coronary angiography (ICA) within 24 hours, but studies show it may not significantly lower death or heart attack rates compared to delayed ICA.
- The study aimed to find the best timing for ICA by analyzing patient data from a national registry, dividing them into three timing groups: early (within 24 hours), intermediate (24-48 hours), and delayed (48-72 hours).
- Results indicated that early ICA led to fewer cases of acute heart failure and shorter hospital stays, but did not significantly affect overall mortality or the rate of hospital readmissions for heart issues after one year.
Opioid use disorder - particularly involving fentanyl - has precipitated a public health crisis characterized by a significant increase in addiction and overdose-related deaths. Fentanyl-specific immunotherapy, which aims at inducing fentanyl-specific antibodies capable of binding fentanyl molecules in the bloodstream, preventing their entry in the central nervous system, is therefore gaining momentum. Conventional opioid designs rely on the covalent conjugation of fentanyl analogues to immunogenic carrier proteins that hold the inherent capacity of mounting immunodominant responses.
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- The study aimed to determine if scalp cooling can enhance the effects of transcranial direct current stimulation (tDCS) on motor cortex excitability.
- It involved 105 healthy participants in a randomized, double-blind design where various tDCS protocols and scalp cooling were tested, with motor evoked potentials measured to assess changes in brain excitability.
- Results indicated that neither tDCS nor scalp cooling produced measurable improvements in motor cortex excitability, suggesting that these methods do not alter cortical excitability effectively.