Publications by authors named "A Banerjea"
Background: Colorectal cancer (CRC) is the third most common cancer in the United Kingdom and the second largest cause of cancer death.
Aim: To develop and validate a model using available information at the time of faecal immunochemical testing (FIT) in primary care to improve selection of symptomatic patients for CRC investigations.
Methods: We included all adults (≥ 18 years) referred to Nottingham University Hospitals NHS Trust between 2018 and 2022 with symptoms of suspected CRC who had a FIT.
Background: Faecal haemoglobin (f-Hb) testing is used in colorectal cancer (CRC) screening and increasingly to guide the investigation in patients with symptoms suggestive of CRC. Studies have demonstrated increased mortality with raised f-Hb.
Aims: To assess the association of raised f-Hb with all-cause, non-CRC (any cause excluding CRC) and cause-specific mortality.
Article Synopsis
- The NuA4/TIP60 complex plays a crucial role in gene regulation and maintaining genome stability by incorporating histone variant H2A.Z and acetylating histones H4, H2A, and H2A.Z.
- Cryo-electron microscopy studies reveal that the EP400 subunit acts as a scaffold, organizing the complex and ensuring correct positioning of functional modules, including the actin-related protein module.
- Loss of the TRRAP subunit disrupts the organization of the NuA4/TIP60 complex, leading to mislocalization and altered acetylation of H2A.Z, highlighting the essential functions of this assembly in cellular processes.
Aim: The aim of this work was to evaluate colorectal cancer (CRC) outcomes after 'low' (sub-threshold) faecal immunochemical test (FIT) results in symptomatic patients tested in primary care.
Method: This work comprised a retrospective audit of 35 289 patients with FIT results who had consulted their general practitioner with lower gastrointestinal symptoms and had subsequent CRC diagnoses. The Rapid Colorectal Cancer Diagnosis pathway was introduced in November 2017 to allow incorporation of FIT into clinical practice.
Article Synopsis
- A retrospective study conducted in Nottingham, UK, investigated whether sociodemographic factors influenced the return rate of faecal immunochemical tests (FIT) among symptomatic patients following a clinical pathway for colorectal cancer initiated in November 2017.
- The study found that 90.7% of patients returned their FIT, with males being less likely to return the test and older patients (≥65 years) being more likely to do so; socioeconomic status and ethnicity also played significant roles in FIT return rates, particularly among those from deprived backgrounds and certain ethnic groups.
- The research identified a total of 599 colorectal cancers (CRCs), mostly detected in individuals who completed their FIT, highlighting the need for strategies to improve FIT return in populations