Titanium Superoxide as a Carrier of a "Long-Lived" Superoxide Anion: An Investigation.

The photoinduced generation of a superoxide anion on the surface of a semiconductor photocatalyst is usually attributed to the reduction of O with conduction-band electrons. In the current work, the reaction of TiO with O giving rise to TiO in superoxide and peroxide states has been investigated with (CAS, CCSD) and DFT (B3LYP) calculations. The ground triplet state and two substates (open-shell singlet (OSS) and closed-shell singlet (CSS)) of a doubly degenerate excited singlet state (Δ) are considered as reactive states of oxygen, participating in spontaneous or photoinduced processes, respectively.

Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action.

The aerosol inhalation delivery of composite particles consisting of Ag nanoparticles enveloped by polyvinylpyrrolidone was investigated in experiments with mice. An ultrasonic nebulizing system was created for the generation of aerosols with a mean diameter and mass concentration of 700 ± 50 nm and 65 ± 5 mg/m, respectively. The mass fraction of Ag in the composite particles was = 0.

The Nature of the Enthalpy-Entropy Compensation and "Exotic" Arrhenius Parameters in the Denaturation Kinetics of Proteins.

Protein unfolding is a ubiquitous process responsible for the loss of protein functionality (denaturation), which, in turn, can be accompanied by the death of cells and organisms. The nature of enthalpy-entropy compensation (EEC) in the kinetics of protein unfolding is a subject of debate. In order to investigate the nature of EEC, the "completely loose" transition state (TS) model has been applied to calculate the Arrhenius parameters for the unfolding of polyglycine dimers as a model process.

Studies of the Specific Activity of Aerosolized Isoniazid against Tuberculosis in a Mouse Model.

The aerosol inhalation delivery of isoniazid in mice was investigated, and the specific activity of the aerosol form of isoniazid was studied with the mouse model of tuberculosis infection, the H37Rv strain. Aerosol delivery was performed using a laminar-flow horizontal nucleation chamber. The inhalation dose was measured in real-time mode using a diffusion aerosol spectrometer.