Synthesis and Structure of 5-Methyl-9-(trifluoromethyl)-12-quino[3,4-][1,4]benzothiazinium Chloride as Anticancer Agent.

In this work, the synthesis, structural analysis and anticancer properties of 5-methyl-9-trifluoromethyl-12-quino[3,4-][1,4]benzothiazinium chloride () are described. Compound was synthesized by reacting 1-methyl-4-butylthio-3-(benzoylthio)quinolinium chloride with 4-(trifluoromethyl)aniline, respectively. The structure of the resulting product was determined using H-NMR and C-NMR spectroscopy as well as HR-MS spectrometry.

World-wide-working-web: How to be successful on global teams.

The day and age where pharmaceutical institutions were securely nestled within solid walls in one country, without much communication and collaboration with other sites and external collaborators, are long gone. The move to more global communication and collaboration has been beneficial for science exploration, however, it has presented scientists with the challenge of working on global teams. This article will explore this world-wide-working web and provide guidance on how to be successful in this new environment in the pharmaceutical industry and related work institutions.

Temporal dynamics of neocortical development in organotypic mouse brain cultures: a comprehensive analysis.

Murine organotypic brain slice cultures have been widely used in neuroscientific research and are offering the opportunity to study neuronal function under normal and disease conditions. Despite the broad application, the mechanisms governing the maturation of immature cortical circuits in vitro are not well understood. In this study, we present a detailed investigation into the development of the neocortex in vitro.

Modulation of large rhythmic depolarizations in human large basket cells by norepinephrine and acetylcholine.

Rhythmic brain activity is critical to many brain functions and is sensitive to neuromodulation, but so far very few studies have investigated this activity on the cellular level in vitro in human brain tissue samples. This study reveals and characterizes a novel rhythmic network activity in the human neocortex. Using intracellular patch-clamp recordings of human cortical neurons, we identify large rhythmic depolarizations (LRDs) driven by glutamate release but not by GABA.