From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota.

The growing prevalence of antibiotic-resistant bacteria within the human microbiome has become a pressing global health crisis. While antibiotics have revolutionized medicine by significantly reducing mortality and enabling advanced medical interventions, their misuse and overuse have led to the emergence of resistant bacterial strains. Key resistance mechanisms include genetic mutations, horizontal gene transfer, and biofilm formation, with the human microbiota acting as a reservoir for antibiotic resistance genes (ARGs).

Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer.

Cancer stem cells (CSCs) are cancer cells responsible for cancer initiation, growth, metastasis, recurrence and resistance to treatment. OCT4 and c-MYC are widely accepted as CSC markers. In this study, we examined the immunohistochemical co-expression of c-MYC and OCT4 with Ki-67 in colorectal cancers (CRC) and the relationship between the results and prognostic and therapeutic data.

Effects of nursing interventions applied at night on sleep quality and sleep effort of patients in the intensive care unit.

This study aimed to evaluate the effect of nursing care interventions applied at night on the sleep quality and sleep effort of intensive care patients. This study is descriptive and cross-sectional in nature. The sample size consists of 82 intensive care patients.

The Effect of Grazing on Central Anatolian Steppe Vegetation: A Modeling Approach Using Functional Traits.

Grazing is a major ecological driver that influences vegetation dynamics globally. We investigated the long-term effects of different grazing regimes on the vegetation structure of the Central Anatolian steppes, a region characterized by its unique convergence of biogeographical influences and historical land use. We employed the spatially explicit FATELAND model to simulate vegetation dynamics over a 50-year period under three distinct grazing scenarios: no grazing, moderate grazing, and overgrazing.

AGK2, a SIRT2 inhibitor, ameliorates D-galactose-induced liver fibrosis by inhibiting fibrogenic factors.

In our study, we aimed to investigate the effect of SIRT2 inhibition on function, fibrosis and inflammation in liver fibrosis induced by D-Galactose (D-Gal) administration. A total of 32 3-month-old Sprague Dawley rats were used in the study. Rats were divided into 4 groups as Control, d-Gal, Solvent+d-Gal, d-Gal+AGK2+Solvent.