Publications by authors named "A Bagcı"
In animals, 18-35-nt piRNAs guide PIWI proteins to regulate complementary RNAs. During male meiosis, mammals produce an exceptionally abundant class of piRNAs called pachytene piRNAs. Pachytene piRNAs are required for spermatogenesis and have been proposed to control gene expression by various mechanisms.
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- In animals, piRNAs work with PIWI proteins to silence transposons, and in species like Drosophila, these RNAs are passed from mother to offspring to kickstart piRNA production.
- This research focuses on the Y-linked piRNA locus Su(Ste) in Drosophila, demonstrating that its piRNAs are generated in male germlines and initiated by maternal transposon piRNAs.
- The study reveals that when XXY mothers deposit Su(Ste) piRNAs, it eliminates the need for sons to produce their own, showcasing a unique way mothers can shield their male offspring through genetic mechanisms.
In eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct AGO-clade Argonaute proteins to regulate gene expression and defend the genome against external threats. Only animals make a second clade of Argonaute proteins: PIWI proteins. PIWI proteins use PIWI-interacting RNAs (piRNAs) to repress complementary transposon transcripts.
View Article and Find Full Text PDFObjective: This study aimed to evaluate the association between left ventricular ejection fraction recovery and the total oxidant status, total antioxidant capacity, and high-sensitivity C-reactive protein levels.
Methods: A total of 264 ST-elevation myocardial infarction patients were classified into two groups according to baseline and 6-month follow-up left ventricular systolic function: reduced and recovery systolic function. Predictors of the recovery of left ventricular ejection fraction were determined by multivariate regression analyses.
Background: Contrast-induced nephropathy (CIN) is a life-threatening complication after primary percutaneous coronary intervention (p-PCI). Oxidative stress and inflammation may play an important role in the development of CIN.
Objective: We aimed to assess the relationship between total oxidant status, total antioxidant capacity, high-sensitivity C-reactive protein (hs-CRP), gamma-glutamyltransferase and uric acid (UA) in the development of CIN in patients presenting with ST-elevation myocardial infarction (STEMI).