Publications by authors named "A Bagayoko"
Objectives: Assess the effectiveness of ring vaccination in controlling an Ebola virus outbreak in the Democratic Republic of Congo.
Methods: This analysis focuses on two areas of the Democratic Republic of Congo, Beni and Butembo/Katwa, which were affected during the 2018-2020 Ebola outbreak. To simulate Ebola virus transmission, we used a spatially explicit agent-based model with households, health care facilities, and Ebola treatment units.
Background: Community-based management of acute malnutrition is an effective treatment model for severe acute malnutrition. However, sparse evidence exists on post-discharge outcomes and the sustainability of recovery. This study aimed to evaluate the risk and determinants of relapse following severe acute malnutrition recovery in high-burden settings.
View Article and Find Full Text PDFrVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the effectiveness and safety of the rVSV-ZEBOV vaccine against Zaire Ebolavirus disease among contacts of EVD survivors, focusing on the influence of pre-existing immunity on vaccination outcomes.
- Ten percent of participants had pre-existing antibodies, but both those with and without antibodies showed significant increases in IgG levels post-vaccination, indicating strong immune responses.
- The findings support the vaccine's safety and suggest that pre-vaccination antibody screening is unnecessary, as it does not negatively impact the immune response to the vaccine.
Article Synopsis
- Pregnancy in women with sickle cell disease (SCD) poses significant risks, particularly due to red blood cell (RBC) alloimmunisation, which complicates transfusion options.
- A study conducted in Bamako between August 2022 and January 2023 involved 95 pregnant women with SCD, revealing that 62% had prior blood transfusions and a 14% prevalence of RBC alloantibodies, with anti-E and pan-agglutinins being the most common.
- The findings indicate that history of miscarriage, blood transfusions, and the number of pregnancies are key risk factors, highlighting the need for improved screening and collaboration among healthcare providers to better manage care for SCD patients during pregnancy.