Publications by authors named "A Badarau"
Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease among infants and young children worldwide, especially in low- and middle-income countries (LMICs). RSM01 is a novel, highly potent, half-life-extended anti-RSV monoclonal antibody (mAb) candidate primarily being developed for LMICs. Here we present the preclinical characterisation and results of a phase 1 trial of RSM01.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the medicinal potential of three Hypericum species: H. alpigenum, H. perforatum, and H. rochelii, with a focus on their bioactive compounds.
- Both maceration and magnetic-stirring-assisted extraction methods were employed to analyze the chemical constituents, revealing key components like phenolic acids and flavonoids.
- H. rochelii was highlighted as particularly rich in beneficial compounds, demonstrating significant antioxidant and antibacterial activities, providing new insights into lesser-studied Hypericum species.
Article Synopsis
- Warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome is primarily linked to mutations in the CXCR4 gene, leading to immune system issues.
- Research evaluated how different CXCR4 mutations affect physical symptoms and the potential of a drug called mavorixafor to mitigate these effects.
- Results indicated that all tested CXCR4 variants had impaired functioning, with a clear connection between the severity of immune symptoms and specific CXCR4 internalization issues, suggesting potential new biomarkers for the syndrome.*
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome (WS) is a combined immunodeficiency caused by gain-of-function mutations in the C-X-C chemokine receptor type 4 (CXCR4) gene. We characterize a unique international cohort of 66 patients, including 57 (86%) cases previously unreported, with variable clinical phenotypes. Of 17 distinct CXCR4 genetic variants within our cohort, 11 were novel pathogenic variants affecting 15 individuals (23%).
View Article and Find Full Text PDF