Statement Of Problem: Denture stomatitis (DS) is a common oral disorder in patients with complete maxillary dentures. Typical treatments such as nystatin or azoles lead to drug resistance after a long period. Several studies have shown the antifungal activity of statins against Candida albicans; however, studies on the antifungal effect of atorvastatin against DS are lacking.
View Article and Find Full Text PDFChronic stress can negatively affect cognitive ability, behavioral functions, and gut microbiota balance. The gut microbiota communicates with the brain through the gut-brain axis to influence brain responses and behavior. The positive effects of psychobiotics and para-psychobiotics (viable and non-viable probiotics, respectively) on decreasing stress and stress-related disorders have been approved, previously.
View Article and Find Full Text PDFObjectives: The objective of this investigation was to compile existing observational research and quantify the potential association between ultra-processed foods (UPFs) and the risk of insomnia using meta-analysis.
Setting: We conducted a systematic search of the PubMed/MEDLINE, Scopus, and ISI Web of Science databases with no restrictions until 29 June 2024. Odds ratios (OR) and 95% confidence intervals (CI) were aggregated using a random-effects model, while the Newcastle-Ottawa Scale and Egger's regression asymmetry test assessed study quality and publication bias, respectively.
Objective: Paraquat (PQ), a widely used non-selective herbicide, induces severe lung toxicity by promoting cell death and tissue necrosis through the generation of reactive oxygen species (ROS) and free radicals. This study aimed to develop and evaluate novel niosomal nanoparticles (NPs) encapsulating curcumin and piperine to mitigate PQ-induced acute pulmonary toxicity in Balb/c mice.
Methods: The NPs were prepared using non-ionic surfactants and cholesterol via the thin film hydration method.