Publications by authors named "A Baassiri"
Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder resulting from a balanced translocation leading to oncogene with increased tyrosine kinase activity. Despite the advancements in the development of tyrosine kinase inhibitors (TKIs), the T315I gatekeeper point mutation in the BCR::ABL1 gene remains a challenge. We have previously reported in a CML model an increased hemocyte count and disruption in sessile hemocyte patterns upon expression of and in the hemolymph.
View Article and Find Full Text PDFSupine [18F]Fluorodeoxyglucose (FDG) positron emission technology/computed tomography (PET/CT) is a commonly used modality for the initial staging of breast cancer, and several previous studies have shown superior sensitivity and specificity of prone FDG PET/CT in comparison to its supine counterpart. This retrospective study included 25 females with breast cancer referred for staging. They underwent supine FDG PET/CT followed by prone FDG PET/CT.
View Article and Find Full Text PDFArticle Synopsis
- * Mutations in the BCR-ABL gene, like the Threonine 315 to Isoleucine change, can make leukemia cells resistant to standard treatments known as tyrosine kinase inhibitors (TKIs).
- * In a research study using fruit flies as a model, expressing both normal and mutated versions of the gene revealed significant impacts on immune cell behaviors and disruptions in important immune pathways, indicating the more severe consequences of the mutation that warrant further study.
Terpenoids are the largest class of natural products, most of which are derived from plants. Amongst their numerous biological properties, their anti-tumor effects are of interest for they are extremely diverse which include anti-proliferative, apoptotic, anti-angiogenic, and anti-metastatic activities. Recently, several in vitro and in vivo studies have been dedicated to understanding the 'terpenoid induced autophagy' phenomenon in cancer cells.
View Article and Find Full Text PDFPurpose: The teaching role of radiology residents has seldom been evaluated, and little is known about how teaching skills of radiology residents evolve throughout their training in the absence of formal teaching guidance. Our objective is to identify residents' characteristics correlating with better teaching and compare teaching characteristics of junior and senior residents.
Method: All seven medical schools in Lebanon were involved in this multi-centric study.