Publications by authors named "A Baartscheer"
Article Synopsis
- SGLT2 inhibitors (SGLT2i) have a direct impact on inhibiting cardiac sodium-hydrogen exchanger-1 (NHE1) activity in heart cells, but previous studies show mixed results that could stem from different methods used in research.* -
- The experiment involved using protease XIV (PXIV) during the isolation of rabbit heart cells and rat cardiomyoblast cells to see if it affects the SGLT2i's ability to inhibit NHE1, exploring various pH levels.* -
- Results showed that while SGLT2i effectively reduced NHE1 activity in cells not treated with PXIV, prolonged exposure to PXIV eliminated this inhibitory effect, highlighting that PXIV
Inflammation causing oxidative stress in endothelial cells contributes to heart failure development. Sodium/glucose cotransporter 2 inhibitors (SGLT2i's) were shown to reduce heart failure hospitalization and oxidative stress. However, how inflammation causes oxidative stress in endothelial cells, and how SGLT2i's can reduce this is unknown.
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- Cardiac arrhythmias are a significant health issue linked to high morbidity and mortality, but understanding their mechanisms is still incomplete, prompting this research to uncover novel pathways behind these conditions.
- Researchers conducted a genetic study using a mouse model that showed early sudden death due to a mutation in the Bcat2 gene, leading to high levels of branched chain amino acids (BCAAs) and cardiac issues such as arrhythmias and disrupted heart function.
- The study found a direct connection between elevated BCAAs and arrhythmias, revealing that mTOR pathway activation plays a critical role, which could impact how we understand and treat these heart conditions.
Aims: SCN5A mutations are associated with arrhythmia syndromes, including Brugada syndrome, long QT syndrome type 3 (LQT3), and cardiac conduction disease. Long QT syndrome type 3 patients display atrio-ventricular (AV) conduction slowing which may contribute to arrhythmogenesis. We here investigated the as yet unknown underlying mechanisms.
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