Publications by authors named "A BEDARD"
Complex genetic and dietary cues contribute to the development of obesity, but how these are integrated on a molecular level is incompletely understood. Here, we show that PPARγ supports hypertrophic expansion of adipose tissue via transcriptional control of LPCAT3, a membrane-bound O-acyltransferase that enriches diet-derived omega-6 ( -6) polyunsaturated fatty acids (PUFAs) in the phospholipidome. In high-fat diet-fed mice, lowering membrane -6 PUFA levels by adipocyte-specific knockout ( ) or by dietary lipid manipulation leads to dysfunctional triglyceride (TG) storage, ectopic fat deposition and insulin resistance.
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- A study investigated how the antioxidant capacity and inflammation potential of maternal diets during the last three months of pregnancy could influence the risk of allergic and respiratory diseases in children.
- Researchers analyzed data from 9,679 mother-child pairs, measuring the dietary antioxidant capacity and inflammatory potential using various indices.
- Results indicated that a diet high in antioxidants was linked to a lower risk of 'early wheeze without asthma,' while a pro-inflammatory diet correlated with a higher risk of 'asthma only,' suggesting maternal diet impacts children's respiratory health to some extent.
Objectives: To develop a web-based food-frequency questionnaire (FFQ) measuring intake of plant-based protein foods (PBP) among older adults from the province of Quebec, Canada.
Design: The questionnaire was adapted from an existing self-administered FFQ and first underwent expert panel evaluation for face and content validity. Then, three phases of cognitive testing were conducted in French, using the probe and think aloud approaches.
Externalizing psychopathology in childhood is a predictor of poor outcomes across the lifespan. Children exhibiting elevated externalizing symptoms also commonly show emotion dysregulation and callous-unemotional (CU) traits. Examining cross-sectional and longitudinal neural correlates across dimensions linked to externalizing psychopathology during childhood may clarify shared or distinct neurobiological vulnerability for psychopathological impairment later in life.
View Article and Find Full Text PDFPurpose: Approximately 5%-10% of patients with pancreatic ductal adenocarcinoma (PDAC) have an inherited basis, yet uptake of genetic testing remains low and subject to disparities. This study compared two genetic testing pathways available to patients referred to a provincial cancer center, BC Cancer: a traditional hereditary cancer clinic-initiated testing (HCT) pathway and a new oncology clinic-initiated testing (OCT) pathway.
Methods: Study subjects were patients with confirmed PDAC referred for genetic testing through the HCT or OCT pathway between June 1, 2020, and February 1, 2022.