Publications by authors named "A B van Vugt"

The local integration of metal nanoparticle films on 3D-structured polydimethylsiloxane (PDMS)-based microfluidic devices is of high importance for applications including electronics, electrochemistry, electrocatalysis, and localized Raman sensing. Conventional processes to locally deposit and pattern metal nanoparticles require multiple steps and shadow masks, or access to cleanroom facilities, and therefore, are relatively imprecise, or time and cost-ineffective. As an alternative, we present an aerosol-based direct-write method, in which patterns of nanoparticles generated via spark ablation are locally printed with sub-mm size and precision inside of microfluidic structures without the use of lithography or other masking methods.

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In 2 cases of men aged 26 and 55 respectively we illustrate the complexity of MUS patients since in both cases a somatic diagnosis was missed. The first patient presented with an inability to walk and persistent pain. Because of his symptoms he lost his job, had depressive moods and used alcohol and cannabis.

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Background: Sacroiliac joint dysfunction (SJD) is a known cause of lower back pain. SJD might be due to hypermobility in the Sacroiliac joint (SIJ) in patients with Ehlers Danlos Syndrome (EDS). Stabilization of the SIJ can be a highly successful treatment for lower back pain.

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Article Synopsis
  • Gain-of-function mutations in guanylyl cyclase C (GCC) lead to persistent diarrhea from birth, and a study explores the GCC inhibitor SSP2518 as a treatment option.
  • The research tested SSP2518's effects on cGMP levels and chloride secretion in intestinal organoids sourced from patients with GCC mutations compared to control organoids.
  • Results showed that SSP2518 lowered cGMP levels in patient organoids to match controls and significantly reduced chloride secretion, suggesting it could help manage diarrhea linked to GCC mutations.
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