Publications by authors named "A B Zonderman"
Article Synopsis
- The study investigates the relationships between sleep quality, global mental status, and the risk of mortality, using data from 1364 participants in the HANDLS study over approximately 8 years.
- Results indicate that poorer sleep quality is linked to a higher mortality risk, particularly among individuals with initially better cognitive function.
- The findings suggest a complex interaction between sleep and cognition affecting mortality risk, highlighting the need for further research to explore these connections over time.
Importance: African Americans have a higher prevalence of Type 2 Diabetes (T2D) compared to White groups. T2D is a health disparity clinically characterized by dysregulation of lipids and chronic inflammation. However, how the relationships among biological and sociological predictors of T2D drive this disparity remains to be addressed.
View Article and Find Full Text PDFAlzheimer's Disease (AD) is a complex polygenic neurodegenerative disorder. Its genetic risk's relationship with all-cause dementia may be influenced by the plasma proteome. Up to 40,139 UK Biobank participants aged ≥ 50y at baseline assessment (2006-2010) were followed-up for ≤ 15 y for dementia incidence.
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- This study investigated how Life's Essential 8 (LE8) impacts cognitive abilities in midlife and older adults, comparing it to Life's Simple 7 (LS7).
- In a sample of 1,539 participants, results showed that higher LE8 scores correlated with improved global cognitive performance, working memory, and attention.
- While LS7 was better for overall cognitive performance, LE8 had stronger links to working memory, indicating differing impacts of cardiovascular health measures on cognitive domains.
Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study.
Transl Psychiatry
October 2024
Longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults remain under-studied, especially across sex, race and levels of anxiety. We examined longitudinal associations of homocysteine (HCY) with depressive symptoms scores among urban adults, before and after stratifying by sex, race and anxiety level, using data from 1460 Healthy Aging in Neighborhoods of Diversity across the Lifespan Study (HANDLS) participants aged 30-64 y at v (2004-2009), followed across 3 visits up to 2017. In addition to LnHcy, we used group-based trajectory models predicting z-transformed likelihood of greater LnHcy with age (Hcy).
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