Publications by authors named "A B Yakovlev"
Article Synopsis
- * Research indicates that exposure to psychoactive substances affects the production and composition of sEVs, with potential differences based on sex.
- * The study suggests there are two mechanisms through which psychoactive substances impact sEVs: a "fast" mechanism that promotes neuroplasticity, and a "slow" mechanism that disrupts the normal production of sEVs.
Article Synopsis
- Hyperhomocysteinemia (hHCY) is linked to increased plasma homocysteine levels and correlates with a higher risk of migraines, especially those with aura.
- The study investigated how hHCY affects cortical spreading depression (CSD) and neuronal activity in the somatosensory cortex of rats, highlighting an increased excitability and more frequent CSDs in those with hHCY.
- Results showed impaired CSD propagation and delayed recovery of brain activity in hHCY animals, indicating that prolonged high homocysteine levels may increase the risk of migraine-associated brain injuries.
Prognostic Value of Ceramide Dynamics in Patients with Acute Coronary Syndrome.
Stud Health Technol Inform
November 2024
A dynamic study of ceramide concentrations and their association with recurrent event risk could enhance our understanding of cardiovascular complications. To assess the prognostic value of ceramide concentrations (Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:1), Cer(d18:1/24:0)) and their dynamics in combination with standard clinical and laboratory parameters and therapeutic interventions in ACS patients. Among 110 ACS patients, triple blood sampling was performed for targeted lipidomic analysis using high-performance liquid chromatography-tandem mass spectrometry.
View Article and Find Full Text PDFAim: To evaluate the efficiency of therapy with Prostatex plus rectal suppositories in the treatment of patients with chronic abacterial prostatitis and benign prostatic hyperplasia (BPH).
Materials And Methods: A total of 50 men with chronic abacterial prostatitis of category III A, occurring in combination with BPH, were included in the study. All patients received Prostatex plus (rectal suppositories) 1 suppository 1 time per day.