Water as a catalyst in the reaction of nitrous acid (HONO) and Criegee intermediate (CHOO).

The present work employs the CCSD(T)/CBS//M06-2X/aug-cc-pVTZ level of theory to investigate the effect of a water monomer (WM) and dimer (WD) on the oxidation of nitrous acid (HONO) by the Criegee intermediate (CHOO). The present work suggests that similar to an uncatalyzed path, a water catalyzed reaction can also proceed two paths, , the oxygen atom transfer (OAT) and the hydrogen atom transfer (HAT) path. In addition, here also, the HAT path dominates over the OAT path.

p53 mediated regulation of LINE1 retrotransposon derived R-loops.

Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons, which comprise 17% of the human genome, typically remain inactive in healthy somatic cells but are reactivated in several cancers. We previously demonstrated that p53 silences L1 transposons in human somatic cells, potentially acting as a tumor-suppressive mechanism. However, the precise molecular mechanisms underlying p53-mediated repression of L1 and its life cycle intermediates remain unclear.

Genistein: A Promising Ally in Combating Neurodegenerative Disorders.

Neurodegenerative disorders arise when nerve cells in the brain or peripheral nervous system gradually lose functions and eventually die. Although certain therapies may alleviate some of the physical and mental symptoms associated with neurodegenerative disorders, hence slowing their progression, but no sure-shot treatment is currently available. It was shown that the rise in life expectancy and the number of elderly people in the community led to an increasing trend in the incidence and prevalence of neurodegenerative disease.