Publications by authors named "A B Urs"

Article Synopsis
  • Researchers are exploring simpler methods for tissue fixation and processing before staining and DNA extraction, with a focus on the AMeX method as a promising alternative to traditional techniques.
  • The AMeX method was tested on human oral mucosal biopsy specimens to assess its effectiveness in H&E staining, immunohistochemistry, and DNA quality.
  • Results indicated that AMeX provided comparable H&E staining results, while enhancing the quality of immunohistochemistry and yielding better genomic DNA quality and quantity.
View Article and Find Full Text PDF

Leukemias arise from recurrent clonal mutations in hematopoietic stem/progenitor cells (HSPCs) that cause profound changes in the bone marrow microenvironment (BMM) favoring leukemic stem cell (LSC) growth over normal HSPCs. Understanding the cross talk between preleukemic mutated HSPCs and the BMM is critical to develop novel therapeutic strategies to prevent leukemogenesis. We hypothesize that preleukemic-LSCs (pLSCs) induce BMM changes critical for leukemogenesis.

View Article and Find Full Text PDF
Article Synopsis
  • Hybrid tumors are complex lesions that contain two or more different pathological entities, but their development isn't well understood.
  • Juvenile trabecular ossifying fibroma (JTOF) is a benign yet locally aggressive type of tumor that mainly affects the maxilla in adolescents.
  • This case report is the first to document the simultaneous occurrence of JTOF with central giant cell granuloma (CGCG) and aneurysmal bone cyst (ABC) in a single patient, along with proposed theories about how this phenomenon might arise.
View Article and Find Full Text PDF
Article Synopsis
  • * A notable case involved a 13-year-old girl with a Schwannoma located in the vestibular mucosa, which is an unusual site for this type of tumor.
  • * Histological examination revealed characteristic features of Antoni type A tissue, and the patient remained free of recurrence six months post-surgery, highlighting the rarity and uniqueness of this case.
View Article and Find Full Text PDF

Hamartomas, a focal excess of normal tissue usually presenting as isolated masses, are rarely found in the head and neck region. The purpose of this report is to discuss a rare case of an intra-oral angioleiomyomatous hamartoma in a 14-year-old male who presented with a congenital nodule over the anterior palatal mucosa. The confirmatory diagnosis was done based on histopathology and immunohistochemistry using various markers.

View Article and Find Full Text PDF