Publications by authors named "A B Tosolini"
Article Synopsis
- Efficient axonal transport is crucial for neuron function, and disruptions can lead to serious neurological disorders.
- The study uses live imaging to show that Nodes of Ranvier (NoR) in different types of motor axons have similar structures, demonstrating how specific organelles like endosomes and mitochondria behave at these nodes.
- Findings enhance our understanding of peripheral nerve physiology and may help in addressing diseases affecting these nerve structures.
We present the design of a portable coronagraph, CATEcor (where CATE stands for Continental-America Telescope Eclipse), that incorporates a novel "shaded-truss" style of external occultation and serves as a proof-of-concept for that family of coronagraphs. The shaded-truss design style has the potential for broad application in various scientific settings. We conceived CATEcor itself as a simple instrument to observe the corona during the darker skies available during a partial solar eclipse, or for students or interested amateurs to detect the corona under ideal noneclipsed conditions.
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- In patients with cystic fibrosis treated with elexacaftor/tezacaftor/ivacaftor (ETI), significant improvements in sinonasal symptoms and a notable increase in nasal nitric oxide (nNO) levels were observed after several months of treatment.
- The study involved measuring nNO levels in 25 PwCF-ETI, 7 PwCF-non ETI, and 32 healthy controls, showing that only the treated group experienced a significant rise in nNO levels, reaching the normal range by follow-up.
- The findings suggest that nNO could be a useful non-invasive biomarker for assessing sinonasal inflammation in cystic fibrosis patients and might correlate
Background: Pulmonary manifestations are the major cause of morbidity and mortality in patients with inborn errors of immunity (IEI). New and more sensitive diagnostic methods can potentially lead to earlier recognition and treatment of IEI lung disease and improve outcome. The aim of this study was to compare multiple-breath washout (MBW) and spirometry in patients with IEI and cystic fibrosis (CF) as well as healthy controls (HC) and to evaluate the sensitivity of lung clearance index (LCI) to assess lung disease in IEI.
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