Publications by authors named "A B Sudarikov"
Introduction: Human cytomegalovirus (Orthoherpesviridae: ) (HCMV) is one of the most commonly detected viruses in recipients of allogeneic hematopoietic stem cell (allo-HSCT) transplants. However, the emergence of resistance to antiviral drugs such as ganciclovir (GCV) poses a challenge in managing these patients. This study aims to investigate the prevalence and impact of mutations in the HCMV UL97 gene associated with resistance to GCV on the course of infection among allo-HSCT patients.
View Article and Find Full Text PDFTumor cells of acute lymphoblastic leukemia (ALL) may have various genetic abnormalities. Some of them lead to a complete loss of certain genes. Our aim was to reveal biallelic deletions of genes in Ph-negative T-ALL.
View Article and Find Full Text PDFMultiple myeloma (MM) is a disease characterized by spatiotemporal heterogeneity of tumor clones. Different genetic aberrations can be observed simultaneously in tumor cells from different loci, and as the disease progresses, new subclones may appear. The role of liquid biopsy, which is based on the analysis of tumor DNA circulating in the blood plasma, continues to be explored in MM.
View Article and Find Full Text PDFArticle Synopsis
- T-cell leukemia from large granular lymphocytes (T-LGL leukemia) is a rare type of cancer, with γδT-LGL leukemia making up about 17% of cases and being linked to autoimmune diseases like rheumatoid arthritis (RA).
- A study analyzed 15 patients with γδT-LGL leukemia and rheumatologic diseases, finding that most had RA, with notable symptoms such as splenomegaly and neutropenia.
- The research highlighted that mutations were common, particularly in certain genes, and showed unusual characteristics of γδT-LGL leukemia, mainly affecting the spleen and not appearing in peripheral blood, prompting the need for further investigation into the relationship between this leukemia and RA.
Article Synopsis
- T-cell large granular lymphocyte (T-LGL) leukemia is characterized by increased large granular lymphocytes in the blood, neutropenia, and splenomegaly, but in rare 'aleukemic' cases, LGL levels are low, complicating diagnosis with related conditions like Felty syndrome in rheumatoid arthritis patients.
- The review discusses the characteristics and variants of aleukemic T-LGL leukemia, particularly the splenic variant, and highlights challenges in distinguishing it from hepatosplenic T-cell lymphoma.
- It emphasizes the importance of genetic testing for mutations in the STAT3 gene and thorough evaluation methods, including next-generation sequencing, for accurate diagnosis of this condition in RA patients.