[Clinical systematics of chronic delusional psychoses in schizophrenia and schizophrenia-spectrum pathology].

Objective: To develop a systematics of chronic delusional psychoses in schizophrenia and pathology of the schizophrenic spectrum that takes into account psychopathological structure (the mechanism of delusional formation) and the trajectories of the disease course (the ratio of negative/positive dimensions).

Material And Methods: The study sample was recruited from the large Moscow psychiatric hospital in 2019-2024 and included 126 patients (94 male, 32 female, mean age 36.5±12.

[Schizophrenia spectrum disorders (aspects of psychopathology and clinical taxonomy)].

Objective: To create a new taxonomy of schizophrenia spectrum disorders (SSD) based on the comparability of the design of SSD and borderline states.

Material And Methods: The total sample consists of 205 patients with an established diagnosis of SSD (F21; F25; F22 according to ICD-10) collected from studies of the department of borderline mental pathology and psychosomatic disorders of the Federal State Budgetary Institution Mental Health Research Center and the Department of Psychiatry and Psychosomatics of Moscow State Medical University in the period 2014 to 2024. Clinical, psychometric, statistical methods were used.

[The new psychopathological paradigm of schizophrenia and schizophrenia spectrum disorders].

The basis of the new paradigm, as an attempt to modernize the systematics of psychopathological disorders, is the concept of simultaneous representation of two relatively independent domains (founded by neurobiological processes) in the clinical space of schizophrenia - negative and positive disorders. The study established the spectra of functional activity of endogenous dimensions, as well as the trajectories of their development, which determine the dominance of predominantly negative or positive symptoms (negative/positive schizophrenia) during the course of the disease. The differentiated impact of endogenous domains on constitutional characterological structures accompanied by the formation of pseudopsychiopathies and subpsychotic personality disorders is observed.

[Bimodal model of delusional psychoses (on the problem of the correlation of paranoid dimensions in the psychopathological space of schizophrenia)].

Objective: To establish clinico-pathogenetic ratios of delusional psychoses constituting the psychopathological space of paranoid schizophrenia and to determine clinical and pathogenetic validity of concepts of a single delusional psychosis (a model of chronic delusion with a staged course) and two endogenous delusional psychoses.

Material And Methods: A sample consisted of 56 patients (19 women, 37 men; the average age 39.7±9.